You will be primarily responsible for the design and synthesis of novel Bicycles and conjugates with a goal of delivering clinical candidates. In this role you will be required to manage external resources to deliver on synthetic and analytical tasks and will also work collaboratively with the scientific team in the UK and US in a project team environment to progress Bicycle’s oncology pipeline.

Whilst we are recruiting for a Senior Scientist, we are also open to an Associate Principal Scientist depending on skills and experience.

You will have demonstrated a high level of proficiency in modern synthetic organic / medicinal chemistry as applied to drug discovery and lead optimization of small molecules and peptides and will be experienced in the application of structure based design, the use of non-natural amino acids, linkers and novel conjugation chemistries. You will work as part of the Medicinal Chemistry team and will contribute to the chemical optimisation of Bicycle monomers... and the design and synthesis of Bicycle oncology agents via external CRO partners. For project centric activities, data and progress review, the role will involve close interaction with the Platform, Biology, in vivo Pharmacology, Translational Sciences and CMC teams.

Key responsibilities:
• Driving chemistry activities within a project team, including the design of bioactive Bicycle® peptides to a set Target Product Profile
• Serve on internal project teams, communicate with project team and colleagues effectively and work well with others to meet experimental and organizational goals.
• Present the results of independently conducted research effectively in oral or written form to line manager, project team members and management level meetings.
• Manage chemistry at external contract research organizations (CROs) including maintaining a good relationship, development of detailed chemistry plans, project tracking, data and compound management, critical evaluation of results and analytical data including NMR, LCMS, HPLC, UV-VIS and troubleshooting synthetic issues.
• Prepare reports and contribute to drafting and reviewing patent filings.
• Prepare manuscripts for submission to peer reviewed journals
• Introducing and developing new innovations which expand the company platform

Qualifications
• Relevant industry or academic experience in contemporary medicinal/peptide chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs
• Experience in structure based drug design and the use of computational modelling and data analysis software to interpret SAR data desirable (activity, selectivity, DMPK characteristics, physical properties etc.)
• Experience in developing drug conjugates or radiopharmaceuticals also desirable
• Demonstrated experience in managing external (CRO, CMO) resources to accomplish project tasks
• Excellent organizational skills and ability to work independently, flexibly and reliably, prioritizing accordingly to the company objectives
• Team player who collaborates and communicates effectively in team environment. Comfort sharing knowledge with wider company team and, as appropriate, report work to the scientific or industry community
• Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment

Additional Information
• State-of-the-art campus environment
• Competitive reward including annual company bonus
• 28 days annual leave in addition to bank holidays
• Employer contribution to pension (employee does not have to contribute)
• Life assurance cover 4x basic salary
• Private Medical Insurance, including optical and dental cover
• Health Cash Plan
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status
Cambridge UK

Salary Criteria