- Principal Scientist, Translational Development, Breast Cancer Disease Lead
- Bristol-Myers Squibb in Princeton, New Jersey, United States
- jobs
- 2 weeks ago
jobs description
Principal Scientist, Translational Development, Breast Cancer Disease Lead
Principal Scientist, Translational Development, Breast Cancer Disease Lead
Apply locations Princeton - NJ - US time type Full time posted on Posted 4 Days Ago job requisition R1589934
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.
You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Translational Medicine at BMS
Translational Medicine is a department within the Research organization that facilitates the transition of drug candidates from early to late-stage clinical development, their approval and life cycle management.
Summary
Reporting to the Oncology Disease Head (Breast Cancer) in Translational Development, the incumbent will be part of the Translational Development team and will help develop translational disease strategies in Breast cancer (BrCa) across multiple asset programs in early and late stage development for approval or life-cycle management in the BMS pipeline. Key responsibility of this role is to effectively collaborate with a cross functional team of asset scientists with deep disease, drug development and business knowledge to help drive an overall translational strategy.
Position
Description:
Develops and executes translational disease strategy in BrCa with deep disease expertise.
Leads and oversees execution of disease strategy including but not limited to various aspects of patient selection strategies.
Serves as scientific expert in generating novel hypotheses for actionable biology based on novel discoveries integrating disease work with literature and deep expertise in BrCa biology.
Manages cross-functional disease project teams with key interfaces in IT, bioinformatics, data sciences, biostatistics, external collaborators, contractors, other disease strategy leads and asset leads.
Maintains relationship with physician scientists for identifying new opportunities and for gaining disease insights.
Identifies needs, gaps and translational disease questions and applies knowledge across all assets in BMS portfolio in the BrCa area.
Leads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients.
Collaborates and guides bioinformatics partners on biological questions to deliver biomarkers and biological understanding from whole transcriptome, whole exome, and/or whole genome data, immune profile and single-cell data.
Manages relationships with key internal stakeholders including Regulatory, Clinical, Commercial, Medical Affairs & Communications and external collaborators to develop translational analysis plans and timelines, communicate analysis results.
Represents the Solid Tumor Translational Development function at various internal meetings and provides domain knowledge and disease expertise to cross-functional teams.
Directs and supports publications in high quality scientific, technical or medical journals.
Qualifications:
PhD degree in a relevant field (e.g. molecular biology, cancer biology, human genetics, immunology).
3+ years post-PhD experience, with demonstrated scientific leadership in integrating, analyzing and interpreting multimodal translational data in an academic and/or industry setting.
Strong background in human cancer genetics, tumor biology & immunology, genomics/multi-omics with deep understanding of tumor-intrinsic and tumor-extrinsic mechanisms driving cancer development and therapeutic resistance.
Extensive knowledge of high-content biomarker platforms and good understanding of the current clinical practice in BrCa.
Ability to work in a fast-paced environment with rapidly changing and competing priorities and ambiguity.
Strong team player with the ability to work in cross-functional teams. Excellent communication and collaboration skills.
Prior experience with clinical trials preferred.
Strong track record of high-quality scientific publications in relevant fields.
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