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Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether.
Mechanism of action
Pain is caused by the stimulation of free nerve endings. When the nerve endings are stimulated, sodium enters the neuron, causing depolarization of the nerve and subsequent initiation of an action potential.
The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.
Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:
Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
Otic Pain (earache)
Surgical or procedural local anesthesia
The demand for benzocaine in European countries such as Spain, Italy, the United Kingdom and Canada in Nouth America is high. Most people use benzocaine for medical purposes, and a small number of people use benzociane for experimental research, or mixing with other chemicals, and unconventional uses. People who are pursuing Lidocaine hydrochloride in the market will also pursue the following local materials: Lidocaine /Lidocaine hydrochloride Procaine/Procaine hydrochloride Benzocaine / cas 94-09-7 Tetracaine/Tetracaine hydrochloride Tetramisole CAS 5036-02-2/ tetramisole hcl CAS 5086-74-8 Phenacetin CAS 62-44-2 Levamisole Hydrochloride CAS 16595-80-5 Tadanafil Powder CAS 171596-29-5 1-Bromo-3,5-dimethyladamantane 1,3-Dimethyladamantane Watermelon ketone
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